HIV感染对患者精液质量的影响
Semen quality and fertility analysis in HIV patients
侯志伟 1李练兵 1吕静 1李新生 1马明福1
作者信息
- 1. 重庆市人口和计划生育科学技术研究院,出生缺陷与生殖健康重庆市市级重点实验室,重庆400020
- 折叠
摘要
目的:探讨HIV感染对患者精液质量的影响.方法:收集5例正常男性和23例HIV感染者的精液样本,采用计算机辅助精液分析系统检测精液参数,并分析HIV病毒感染对精液质量的影响.结果:HIV感染者和正常男性的精液质量比较,精子密度、总数、活力、活率均较对照组显著降低(P均<0.01),而畸形率显著升高(P<0.01),HIV感染者精液中CD4+ T淋巴细胞数低于健康男性,CD4+ T淋巴细胞数与精子活率和活力相关(r=0.787和0.770,P<0.01).结论:HIV感染对男性的精液质量造成严重损伤,有可能降低患者的生育能力.
Abstract
OBJECTIVE: To investigate the impact of HIV infection on semen quality and fertility.METHODS: Semen were collected from 5 healthy adult males and 23 HIV-infected males. Then routine semen parameters were measured by computer-assisted semen analysis system. Meanwhile, the influence of virus infection on the semen quality was analyzed. RESULTS: Comparing semen quality between healthy and HIV-infected adults, there was difference in sperm concentration, total sperm count, sperm vitality, sperm motility rate and sperm deformity rate (P ＜ 0.01). The sperm concentration and total sperm count were 3 times lower in HIV-infected men. The sperm vitality and sperm motility were 3 fold more in healthy men. The sperm deformity was 2 fold more in HIV-infected men. The CD4+ T lymphocytes count in the semen from HIV-infected men was lower than that from healthy men, and there was significant correlation between CD4+ T lymphocytes count and sperm motility rate and sperm vitality ( r= 0.787 and 0.770, P ＜ 0.01).CONCLUSION: HIV infection would seriously impact the semen quality and may decrease the fertility rate.
关键词
HIV/精液质量/生育力Key words
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基金项目
出生缺陷与生殖健康重庆市市级重点实验室项目(08-03)
出版年
2011
国家科技期刊平台
NSTL
维普
万方数据