Clinicopathological roles of IL-17A and estrogen receptors α,β in epithelial ovarian cancer
OBJECTIVE:To investigate expression levels of interleukin(IL)-17A and estrogen receptor α(ERα)and ERβ in epithelial ovarian cancer(EOC)tissues and their relationship with clinicopathological features and prognosis.METHODS:Clinical and pathological data of 102 EOC patients admitted to Wuxi Maternal and Child Health Hospital during August 2018-August 2022 were retrospectively analyzed.IL-17A,ERα,and ERβ mRNA expressions in cancer tissues and paracellular tissues were detected by real-time fluorescence quantitative PCR(qPCR),and the ERα/β ratio was calculated.The relationships between IL-17A mRNA,ERα/β and clinicopathological features were analyzed.Effects of IL-17A mRNA,ERα/β on the prognostic overall survival of EOC were analyzed by the Kaplan-Meier method and Cox regression analysis.RESULTS:Expressions of IL-17A,ERα and ERα/β were higher in the cancer than the paracancer tissues,while the expression of ERβ was decreased(P<0.05).The high and low expression groups of IL-17A and ERα/β were divided by the mean values of 0.52 and 3.85,respectively,and the results showed that high IL-17A expression and high ERα/β ratio were associated with FIGO stage,lymph node metastasis,and the amount of ascites(P<0.05).The follow-up period ranged from 12 to 60 months,with a median follow-up period of 36 months,and a total of 38 cases(37.25%)died during the follow-up period.Kaplan Meier analysis showed that the cumulative survival rate of those with high IL-17A mRNA expression was lower than that of those with low expression(P<0.05),and the cumulative survival rate of those with high ERα/β ratio was lower than that of those with low ERα/β ratio(P<0.05).Multifactorial Cox analysis showed that FIGO stage III + IV,postoperative residual foci>2 cm,high expression of IL-17A mRNA,and high ERα/β ratio were independent risk factors for overall survival in patients with EOC(P<0.05).CONCLUSION:IL-17A,ERα and ERα/β were up-regulated while the ERβ mRNA level was down-regulated in EOC,and the prognosis of EOC patients with high IL-17A expression and high ERα/β ratio was poor.
万方数据
维普
