A retrospective analysis on the impact of size-and source-specific ambient particles on preeclampsia
OBJECTIVE:This study aimed to examine the impact of size-segregated and source-specific ambient particles on preeclampsia risk.METHODS:This study was conducted based on the antenatal examination records from Maternal and Child Health Hospital from 2014-2018 in Beijing,China.Particle number concentrations(PNC)of particles in size fractions of 5-560 nm and meteorological data in this study area were collected.The sources of PNC5-560 were apportioned using the positive matrix factorization method.Logistic regression was used to analyze associations between maternal exposure to ambient particles and preeclampsia risk.RESULTS:Maternal exposure to particles in size fractions of 5-200 nm during preconception and early pregnancy was associated with increased risk of preeclampsia.Per an interquartile range(IQR)increment in PNC25-100 and PNC100-200 exposure during preconception,the excess risks of PE increased by 36%[OR(odd ratio)=1.36,95%CI(1.04,1.76)]and 40%[OR=1.40,95%CI(1.12,1.76)],respectively.Per an IQR increment in PNC5-25 and PNC100-200 exposure during early pregnancy,the excess risks of PE increased by 46%[OR=1.46,95%CI(1.15,1.83)]and 40%[OR=1.40,95%CI(1.08,1.82)],respectively.Maternal exposure to nucleation and gasoline vehicle emissions during preconception and early pregnancy was associated with the risk of preeclampsia.CONCLUSION:Maternal exposure to traffic-related ultrafine particles during preconception and early pregnancy may increase the risk of preeclampsia.
国家科技期刊平台
NSTL
万方数据
