OBJECTIVE:To investigate teratogenicity of isoproturon in rats.METHODS:Pregnant Wistar rats were divided into 4 groups of 15 rats per group.Control group(peanut oil)and isoproturon(36.9,73.8 and 369.0 mg/kg)were administered by gavage once per day from day 6 th to 15th of gestation.Rats were killed at the 20th day of gestation,maternal and embryonic developmental indicators were examined.RESULTS:Compared to the control group,all observation indicators of 36.9 and 73.8 mg/kg of isoproturon group were no statistically significant difference(P＞0.05).On the 9th day,the 369.0 mg/kg group showed signs of fatigue,fluffy back hair,and significantly lower body weight(P＜0.01).The implantation counts and live fetus counts were lower(P＜0.5),dead embryos were increased and the average body weight of the litters were significantly less than that in the control group(P＜0.5,P＜0.01).Abnormalities were observed such as widened fontanelle,occipital ossifications,and incomplete and rib bending.The skeleton malformation rate of 27.78％was increased compared to the control group(P＜0.05).CONCLUSION:Under our conditions,369.0 mg/kg of isoproturon treatment induced maternal toxicity and embryonic developmental toxicity in Wistar rats.
万方数据
维普
