Clinicopathological characterization of HER-2-low cases among breast cancers
OBJECTIVE:To study the proportion of HER-2-low expression in breast cancer and the clinicopathological characteristics of HER-2-low breast cancer.METHODS:From January 2019 to December 2023,982 cases of invasive breast cancer cases that were treated in the Shenzhen Maternal and Child Healthcare Hospital were collected.Immunohistochemistry(IHC)was used to detect the expression of human epidermal growth factor receptor-2(HER-2),hormone receptors including estrogen receptor(ER)and progesterone receptor(PR),and cell proliferation related protein Ki-67.Fluorescence in situ hybridization(FISH)was used to detect HER-2 gene amplification.The clinicopathological data such as the patients'age,tumor diameter,histological grades of tumor and lymph node metastasis status were retrospectively studied to analyze the proportion of HER-2 low expression in breast cancer cases and the difference in clinicopathological characteristics between HER-2-low breast cancer and HER-2 negative/positive breast cancer.RESULTS:Among the 982 cases,567(57.74％)were HER-2-low,194(19.76％)were HER-2 negative,and 221(22.50％)were HER-2 positive.The histological grade and Ki-67 proliferation index of HER-2-low breast cancer were lower than those of HER-2 negative and HER-2 positive breast cancer(all P＜0.01).The lymph node metastasis rate in HER-2-low breast cancer was higher than it in HER-2 negative breast cancer,but lower than it in HER-2 positive breast cancer(all P＜0.01).The positive rate of hormone receptors in HER-2-low breast cancer was higher than that in HER-2 positive breast cancer(P＜0.01),but no significant difference with HER-2 negative breast cancer.There was no significant difference between HER-2-low breast cancer and HER-2 negative or HER-2 positive breast cancer in terms of patients'age and tumor diameter.CONCLUSION:Breast cancer with low HER-2 expression accounted for a high proportion of the overall breast cancer cases,and showed low histological grade,low Ki-67 proliferation index,but high hormone receptor positivity rate.These characteristics may affect therapeutic efficacy.
万方数据
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