Involvement of selenium levels in serum and iodine levels in urine with thyroid cancer:a meta-analysis
OBJECTIVE:To investigate involvement of serum selenium and urine iodine concentrations(UIC)with thyroid cancer through meta-analysis.METHODS:Systematic search was conducted through PubMed,Web of Science,Wanfang Database and CNKI for relevant publications up to November 2023.Meta-analyses were performed using Review Manager 5.4.1 and Stata 17.RESULTS:A total of 18 reports including 22 case-control studies with 6 457 participants were included.Pooled analysis showed that the serum selenium level of thyroid cancer patients was lower than that of healthy controls[SMD=-1.46,95％CI=(-2.21,-0.72),P=0.001].Compared with the healthy control group,excessive iodine intake(UIC≥300 μg/L)was positively correlated with the occurrence of thyroid cancer[OR=2.68,95％CI=(1.40,5.12),P=0.003],and the appropriate iodine intake(100≤UIC＜200 μg/L)was negatively correlated with the occurrence of thyroid cancer[OR=0.47,95％CI=(0.29,0.76),P=0.002],and insufficient iodine intake(UIC＜100 μg/L)[OR=0.62,95％CI=(0.35,1.09),P=0.10]and minor iodine overdose(200≤UIC＜300 μg/L)[OR=0.81,95％CI=(0.50,1.32),P=0.40]were not statistically significant with the occurrence of thyroid cancer.CONCLUSION:This meta-analysis indicates that decreased serum selenium levels may elevate the risk of developing thyroid cancer,whereas excessive iodine intake could serve as a potential risk factor for thyroid cancer.Conversely,moderate iodine intake may confer protection against thyroid cancer.
万方数据
维普
