Synthesis of Related Impurities G of Selegiline Hydrochloride
In the EP standard of selegiline hydrochloride,impurity G is the addition product of HCl homoalkyne bond(a mixture of cis Ga and trans Gb).This impurity belongs to a warning structure and cannot be purchased from the market.We synthesized this impurity G(Ga,Gb)and obtained its isomer Gc(a new compound)in combination with the analog literature.During the high temperature test and accelerated stability test in the influence factor experiment,the selegiline hydrochloride preparation will be partially degraded into the impurity Gb and its isomer Gc.The synthe-sis of these three impurities provides support and assistance for the study of the impurity profile of selegiline hydrochlo-ride and the establishment of quality standard in the future.
selegiline hydrochloridewarning structuresynthesisisomerquality standard
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