Studies on Synthesis and Bioactivity of 5-Amino-Imidazole Derivatives
In the paper,we synthesis of a series of 5-aminoimidazole compounds by one pot reaction at room tempera-ture,with aryl thiourea and isocyanide as starting materials,DBU as catalyst,and DMF as solvent.Then confirm the structure through NMR,HRMS(ESI),and m.p..Meanwhile,the biological activity of the compounds were studied by MTT,and the results showed that them have a strong inhibitory effect on tumor cells,it provides ideas for the develop-ment of new anticancer drugs.
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