Research Progress in pH Acid-Sensitive Maleic Acid Amide Bonds
Compared with traditional treatment methods, nano drug delivery system has better biocompatibility, targeting, control or continuous drug release and other advantages, which greatly improves patient compliance. Significantly enhance EPR effect and reduce the toxic side effects of drugs. Due to pH differences in the human microenvironment, pH-sensitive chemical bonds have been extensively studied as stimulus response factors in nanodrug delivery systems. Among them, ma-leic amide derivatives have attracted much attention due to their interesting properties and potential. In this paper, the thixotropic mechanism of ph-sensitive maleidoamide bond and the mechanism of chemical bond breaking and protonation control are introduced in detail. The advantages of the chemical structure of maleic acid amide bond and its application in nano drug delivery system were analyzed and discussed.
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