2,3-二氯吡啶合成工艺研究
Study on the Synthesis Process of 2,3-Dichloropyridine
刘敏 1张明祥 1周淳 1赵伟杰 1杜承建1
作者信息
- 1. 安徽国星生物化学有限公司,安徽马鞍山 243100
- 折叠
摘要
以DBU修饰的M/MCM-41为催化剂,固定床为反应器,采用2,3,6-三氯吡啶为原料,H2氛围下,还原反应合成2,3-二氯吡啶.系统考查了金属种类、金属含量、反应温度、反应压力以及空速的影响,筛选出最优的反应条件:4％的Pd/MCM-41-DBU为催化剂,温度为80℃,压力为0.6 MPa,空速为0.4 h-1,2,3,6-三氯吡啶∶甲苯∶三乙胺=1∶6∶1.2(摩尔比),此条件下2,3-二氯吡啶的收率最高,达94.1％.该工艺操作简单,安全性高,收率高,适合工业化生产.
Abstract
The 2,3-dichloropyridine was synthesized by using the 2,3,6-trichloropyridine as raw material in fixed bed re-actor.The influence of metal type,metal content,residence temperature,pressure and airspeed were systematically investi-gated,and suitable reaction conditions were selected.The optimal conditions for diazotization were as follows:metal type was Pd,metal content was 4％,the temperature was 80℃,the pressure was 0.6 MPa and the airspeed was 0.4 h-1,the yield of 2,3-dichloropyridine was the highest,at 94.1％,respectively.The process realizes the continuous synthesis of 2,3-di-chloropyridine has high safety and high yield,and is suitable for industrial production.
关键词
DBU修饰的M/MCM-41/2,3,6-三氯吡啶/还原反应/固定床/2,3-二氯吡啶Key words
DBU modified M/MCM-41/2,3,6-trichloropyridine/reduction reaction/fixed bed reactor/2,3-dichloropyri-dine引用本文复制引用
出版年
2024
NETL
NSTL
万方数据