Research Progress of Metal-Free Synthesis of the Pyrimidine Framework
Pyrimidine compounds play an important role in medicines for the treatment of many diseases because of the good biological activity. Among these,the methods for the synthesis of pyrimidine compounds are of great value in the field of synthetic and medicinal chemistry. This review focuses on metal-free approaches to synthesis pyrimidine framework. By analysing the reaction mechanisms,problems with existing reactions are pointed out and new methods for the synthesis of pyrimidine framework are envisaged.
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