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温度响应型水凝胶的生物应用研究

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温度响应型水凝胶是目前研究最广泛的一种智能响应型水凝胶,在低温下呈现溶液状态,可以被注射;注射到体内后,体温的刺激使处于溶液状态的水凝胶材料原位凝胶化,覆盖在皮肤/组织表面.主要阐释了温度响应型水凝胶的温度响应机理及其在生物领域中的应用,结合国内外相关研究,讨论了近年来温度响应型水凝胶向临床转化存在的问题及未来研究的方向.
Biological Application of Temperature Responsive Hydrogels
Temperature responsive hydrogel is one of the most widely studied intelligent responsive hydrogels,which can be injected in solution at low temperature. After injection into the body,the stimulation of body temperature causes the hy-drogel material in solution to gel in situ,covering the skin/tissue surface. This review mainly explains the temperature re-sponse mechanism of temperature-responsive hydrogels and their applications in the biological field. Combined with rel-evant researches at home and abroad,the problems existing in the clinical transformation of temperature-responsive hydro-gels in recent years and the future research direction are discussed.

temperature responsive hydrogelin situ gelationbiological applicationsclinical transformation

孙天赐、陈祥顺、许逊、王俊、宁仁德、李庆、何涛

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合肥工业大学化学与化工学院,安徽合肥 230009

安徽医科大学,安徽合肥 230009

中国科学技术大学,安徽合肥 230022

温度响应型水凝胶 原位凝胶化 生物应用 临床转化

2024

安徽化工
安徽省化工研究院

安徽化工

影响因子:0.229
ISSN:1008-553X
年,卷(期):2024.50(4)