首页|姜黄素/替莫唑胺脂质纳米粒的制备工艺研究

姜黄素/替莫唑胺脂质纳米粒的制备工艺研究

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目的:制备共载姜黄素(Cur)/替莫唑胺(TMZ)的脂质纳米粒(lipid nanoparticles,Cur/TMZ-LN).方法:用薄膜分散法、反复冻融法、载体沉积法等制备Cur/TMZ-LN,以包封率为评价指标选出最佳制备方法并进行单因素考查.结果:确定反复冻融法为最佳制备方法,且冻融次数为3,磷脂、胆固醇比为6∶1,磷脂浓度为3mg/Ml,姜黄素包封率为89.23％,替莫唑胺包封率为44.65％.结论:利用反复冻融法制备姜黄素/替莫唑胺脂质纳米粒,包封率较高,粒径较小.
Preparation of Curcumin/Temozolomide Lipid Nanoparticles
Objective:Prepare lipid nanoparticles (Cur/TMZ-LN) co-loaded with curcumin (Cur) and temozolomide (TMZ). Methods:Cur/TMZ-LN was prepared by thin film dispersion,repeated freezing-thawing and carrier deposition. The best preparation method was selected based on the encapsulation efficiency. Results:The method of repeated freez-ing-thawing was confirmed,and the times of freezing-thawing were 3,the ratio of phospholipid to cholesterol was 6∶1,the concentration of phospholipid was 3 mg/mL,the entrapment efficiency of curcumin was 89.23％,the entrapment effi-ciency of temozolomide was 44.65％. Conclusion:Curcumin/temozolomide lipid nanoparticles were prepared by repeated freezing-thawing method with high entrapment efficiency and small particle size.

curcumintemozolomidelipid nanoparticlesrepeated freeze-thaw method

陈静、梅玥、季颖、陈璟、吕志阳

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南京中医药大学翰林学院,江苏泰州 225300

姜黄素 替莫唑胺 脂质纳米粒 反复冻融法

江苏省高校自然科学基金江苏省高校自然科学基金江苏省中医药科技发展计划项目泰州市社会发展支撑项目泰州市社会发展支撑项目2023年江苏省大学生创新创业训练项目2023年江苏省大学生创新创业训练项目2023年江苏省大学生创新创业训练项目

21KJB36002122KJB360014YB2020108SSF20220004SSF20230030202313981013Y202313981008Y103152023059

2024

10.3969/j.issn.1008-553X.2024.04.009

安徽化工
安徽省化工研究院

安徽化工

影响因子：0.229
ISSN：1008-553X
年,卷(期)：2024.50(4)