2,2′-联吡啶合成工艺研究
Study on the Synthesis Process of 2,2′-Bipyridine
蒋伟 1赵运明 1吴凤培 1夏诗宽 1刘敏1
作者信息
- 1. 安徽国星生物化学有限公司,安徽马鞍山 243100
- 折叠
摘要
以NiAPO-34分子筛为催化剂,固定床为反应器,采用吡啶为原料偶联反应合成2,2′-联吡啶.系统考查了金属含量、催化剂用量、反应温度、反应压力以及空速的影响,筛选出合适的反应条件.在NiO∶Al2O3摩尔比为0.06∶1,催化剂用量70％,反应温度为400℃,反应压力为0.6MPa,空速为0.6h-1的最优条件下,2,2′-联吡啶收率和选择性最高,分别为83％和90.2％.该工艺操作简单,安全性高,收率高,适合工业化生产.
Abstract
2,2′-Bipyridine was synthesized by using the pyridine as raw material in fixed bed reactor. The influence of NiO∶Al2O3 ratio,catalyst amount,residence temperature,pressure and airspeed was systematically investigated,and suit-able reaction conditions were selected. The optimal conditions for diazotization were as follows:the ratio of NiO∶Al2O3 was 0.06∶1,the amount of catalyst was 70％,the temperature was 400℃,the pressure was 0.6 Mpa and the airspeed was 0.6 h-1,the yield and selectivity of 2,2′-bipyridine were the highest,at 83％ and 90.2％,respectively. The process realizes the continuous synthesis of 2,2′-bipyridine has high safety and high yield,and is suitable for industrial produc-tion.
关键词
NiAPO-34/分子筛/吡啶/偶联反应/固定床/2,2′-联吡啶Key words
NiAPO-34/molecular sieves/pyridine/coupled reaction/fixed bed reactor/2,2′-bipyridine引用本文复制引用
出版年
2024
NETL
NSTL
万方数据