Study on the Continuous Synthesis of 3-Bromopyridine
3-Bromopyridine was synthesized continuously in a two-stage tubular reactor. The molar ratio of pyridine,hy-drobromic acid and hydrogen peroxide was 1∶3∶1.2. The temperature of the first-stage tubular reactor was 50℃ and the residence time was 5 min. The temperature of the second-stage tubular reactor was 90℃ and the residence time was 20 min. The conversion rate of pyridine reached 99.2％ and the reaction yield was 80.6％. The content of 3-bromopyridine reached 98.5％ by negative pressure distillation. The process of synthesis and separation is energy saving and high effi-ciency,which is a suitable route for industrial production.
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