3-溴吡啶连续化合成工艺研究
Study on the Continuous Synthesis of 3-Bromopyridine
谷顺明 1刘国良 1张正涛 1金文娟 1温兰兰1
作者信息
- 1. 安徽国星生物化学有限公司,安徽马鞍山 243100
- 折叠
摘要
采用分段式管式反应器连续化合成3-溴吡啶,当吡啶、氢溴酸和双氧水按摩尔比为1∶3∶1.2,一段管式反应器温度为50℃,停留时间为5min,二段管式反应器温度为90℃,停留时间为20min时,吡啶转化率达到99.2％,反应收率达到80.6％.采用负压精馏提纯,3-溴吡啶含量达到98.5％以上.合成与分离过程节能、高效,适合工业化生产.
Abstract
3-Bromopyridine was synthesized continuously in a two-stage tubular reactor. The molar ratio of pyridine,hy-drobromic acid and hydrogen peroxide was 1∶3∶1.2. The temperature of the first-stage tubular reactor was 50℃ and the residence time was 5 min. The temperature of the second-stage tubular reactor was 90℃ and the residence time was 20 min. The conversion rate of pyridine reached 99.2％ and the reaction yield was 80.6％. The content of 3-bromopyridine reached 98.5％ by negative pressure distillation. The process of synthesis and separation is energy saving and high effi-ciency,which is a suitable route for industrial production.
关键词
管式反应器/连续化合成/3-溴吡啶/负压精馏Key words
tubular reactor/continuous synthesis/3-bromopyridine/negative pressure distillation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据