6-溴喹啉分析检测方法的研究
Study on 6-Bromoquinoline Analysis and Detection Method
焦剑1
作者信息
- 1. 安徽英特美科技有限公司,安徽蚌埠 233000
- 折叠
摘要
建立6-溴喹啉高效液相色谱检测方法,优先选用C18柱作为分离色谱柱;选择三氟乙酸乙腈溶液及三氟乙酸水溶液作为流动相,并以梯度洗脱的方式进行;检测器为紫外检测器,检测波长为240nm.利用卡尔·费休水分测定仪研究6-溴喹啉水分含量.最后对检测方法的准确度和精密度进行了验证研究.
Abstract
Establish a high-performance liquid chromatography detection method for 6-bromoquinoline,prioritizing C18 column as the separation column. Select trifluoroacetic acid acetonitrile solution and trifluoroacetic acid aqueous solution as mobile phases,and perform gradient elution. The detector is an ultraviolet detector with a detection wavelength of 240 nm. Using a Karl Fischer moisture analyzer,study the moisture content of 6-bromoquinoline. Finally,a validation study was conducted on the accuracy and precision of the detection method.
关键词
液相色谱/喹啉类化合物/药物中间体/有机合成/卡尔费休Key words
liquid chromatography/quinoline compounds/drug intermediates/organic synthesis/Karl Fischer引用本文复制引用
出版年
2024
NETL
NSTL
万方数据