首页|盐酸司来吉兰中两种致突变杂质的合成方法与含量测定

盐酸司来吉兰中两种致突变杂质的合成方法与含量测定

Synthesis Method and Content Determination of Two Mutagenic Impurities in Selegiline Hydrochloride

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药物杂质是影响药物质量的重要因素,尤其是致突变杂质.盐酸司来吉兰中潜在存在两种新型的致突变杂质,探索了它们的合成方法并在药物中测定其含量,确定了它们的控制策略.
Drug impurities are important attributes that affect drug quality,especially mutagenic impurities. There are two potential new types of mutagenic impurities in selegiline hydrochloride. We explore their synthesis methods and de-termine their content in the drug to determine their control strategies.

mutagenic impuritiesselegiline hydrochloridesynthesis and analysis

蔡玉磊、程俊、彭介伟、张祖良、王尧、田磊

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安徽贝克生物制药有限公司,安徽合肥 230088

致突变杂质 盐酸司来吉兰 合成与分析

2024

安徽化工
安徽省化工研究院

安徽化工

影响因子:0.229
ISSN:1008-553X
年,卷(期):2024.50(4)