Effects of the ethanol extract of Dendrobium officinale on gut microbiota of dysbacteriosis mice
To explore the effects of ethanol extract from Dendrobium officinale on the gut microbiota of antibiotic induced dysbiosis mice,a blank group and a gut microbiota dysbiosis model group(gavage of lincomycin hydrochloride 120 mg/kg)were set up,respectively.The model group was treated with normal water,high(6 g/kg)and low dose(1.5 g/kg)of ethanol extract from Dendrobium officinale,and the effects of each treatment on the general condition,TNF-α,IL-1 levels,short chain fatty acid levels,gut microbiota composition,richness,and diversity of mice were observed.The results showed that the general mental condition of mice in the high-dose and low-dose groups of Dendrobium officinale improved,and the levels of serum TNF-α and IL-1 were significantly reduced compared to the model group,while the levels of short chain fatty acids were significantly increased.There were differences in the species composition of gut microbiota compared to the model group,but no significant differences in richness and diversity.The ethanol extract of Dendrobium officinale had a certain improvement effects on the gut microbiota of antibiotic induced intestinal dysbiosis mice.
万方数据
维普
