Screening of active ingredients in Wubiefanchun oral liquid based on network pharmacology
Wubiefanchun oral liquid is a kind of product which combines the characteristics of modern medicine and food.The active ingredients were found by using TCMSP database and related literature using network pharmacology method.The potential targets of active ingredients were predicted by SwissTargetPrediction and PharmMapper databases,and the related targets were searched and screened in Genecards,DisGeNET and OMIM databases.The protein-protein interaction(PPI)network of the potential target was constructed using STRING database,and the key target network of the active ingredient of the oral liquid was screened out,and the GO function and KEGG pathway enrichment analysis were performed on these key targets to determine their core pathway,so as to construct the action network of the active ingredient of the oral liquid.The results showed that a total of 75 active ingredients were obtained,384 potential targets were obtained based on the active ingredients,and 75 key targets were obtained through potential target PPI network screening.GO was enriched to 892 entries and KEGG was enriched to 164 pathways.Based on the above results,the mechanism of action of the active ingredients of the oral liquid may be realized through the action of rhubarb anthraquinones,flavonoids and phytosterols on the core targets of AKT1,TNF and IL6,with PI3K-Akt,HIF-1,mTOR and FoxO as signaling pathways.
Wubiefanchun oral liquidhomology of medicine and foodscreening of active ingredientsnetwork pharmacology
万方数据
维普
