Research on the lipid-lowering function of Lactobacillus gasseri in hyperlipidemic mice
To investigate the lipid-lowering effect of Lactobacillus gasseri on hyperlipemia mice,30 mice were randomly divided into control group(ordinary diet+200 μL normal saline),hyperlipemia group(high-fat diet+200 μL normal saline)and Lactobacillus gasseri group(high-fat diet+1×109 CFU live Lactobacillus gasseri),cultivated for 14 days.The changes of body weight and fat mass of mice were monitored,and the levels of blood lipids and liver fat were detected.The results showed that,compared with the high-fat group,the body weight,fat mass,the contents of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in serum,as well as the contents of TC and TG in liver of high-fat mice were decreased by the administration of live Lactobacillus gasseri.In conclusion,Lactobacillus gasseri can effectively regulate the lipid metabolism process of mice,improve the lipid abnormalities of hyperlipidemic mice,and show a good lipid-lowering effect.
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