Research progress of exogenous compounds to slow the toxic effects of AFB1
Aflatoxin B1(AFB1)is a kind of Aflatoxin(AFs),which mainly exists in mouldy feed.To understand the research progress of exogenous compounds that can mitigate the toxic effects of AFB1,this paper describes the physicochemical properties of AFs and AFB1,as well as the metabolic detoxification process of AFB1 in vivo,and combs out 8 exogenous compounds that can alleviate AFB1 poisoning,such as curcumin,vitamin E and yeast selenium,and their mechanisms of action.AFs is a kind of toxin produced by Aspergillus flavus and Aspergillus parasiticus.The liver is the main target organ,which has strong carcinogenic,malformation and mutagenicity.Among them,AFB1 is the most toxic,which can cause oxidative stress,cell apoptosis,gene mutation and immune system damage,etc.In animals,it is mainly metabolized and detoxicated by enzymes such as CYP450s.The common mechanism of action of exogenous compounds such as curcumin is to inhibit or induce the activity of metabolic enzymes in vivo,change the metabolic rate and pathway of toxins,and alleviate the oxidative stress state of animals,so as to slow down the toxic effects of AFB1.This paper provides references for screening new detoxification drugs and clinical treatment of animal AFB1 poisoning.
NETL
NSTL
万方数据
