Objective:To explore the application value of procalcitonin (PCT), interleukin-6 (IL-6) combined with platelet (PLT) detection in the early diagnosis of patients with extensive burn complicated with sepsis. Methods:A retrospective study was performed on the medical records of 101 patients with extensive burns who were admitted to the Hospital. Patients were categorized into two groups: a sepsis group and a control group, based on the presence or absence of sepsis. The levels of Platelets (PLT) on the third day and serum Procalcitonin (PCT) and Interleukin-6 (IL-6) on the seventh day were compared between the two groups. The value of combined detection of serum PCT, IL-6, and PLT in the early diagnosis of sepsis in patients with major burns was evaluated using Receiver Operating Characteristic (ROC) curve analysis.Results:The levels of serum PCT and IL-6 were higher in the sepsis group than those in the control group, while the level of PLT was lower, and the differences were statistically significant (P<0.05). The ROC curve analysis showed that the AUCs of the single and combined detection of PCT, IL-6, and PLT were 0.935, 0.794, 0.904, and 0.961, respectively.Conclusions:PCT, IL-6, and PLT all exhibit high diagnostic value in the early detection of sepsis in patients with extensive burns. The efficiency of their combined testing is optimal. This holds significant value for the early clinical diagnosis of sepsis in patients with extensive burns.
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