Objective:To analyze the effect of remifentanil combined with propofol in laparoscopic cholecystectomy. Method:Patients who underwent laparoscopic cholecystectomy were sequentially included in the control group (n=39, receiving sufentanil combined with propofol anesthesia) and the study group (n=39, receiving remifentanil combined with propofol anesthesia). Observe the anesthesia outcomes of two groups; The level of hemodynamic indicators; Postoperative stress situation; Postoperative adverse reactions. Result: Compared with the control group, the study group had earlier recovery time of consciousness, extubation time, recovery of spontaneous breathing time, pain relief time, and eye opening time (P<0.05). The heart rate, arterial diastolic pressure, and arterial systolic pressure were lower after establishing pneumoperitoneum and extubation P<0.05). At the same time, the levels of adrenaline and cortisol were lower after anesthesia recovery (P<0.05), and the patients were restless, nauseous, and vomiting after anesthesia recovery The total proportion of adverse reactions such as dizziness and headache was lower (P<0.05). Conclusion:The combination of remifentanil and propofol has the ability to reduce the risk of postoperative adverse reactions and physiological stress in patients undergoing laparoscopic cholecystectomy, while also stabilizing patient hemodynamics and promoting early recovery.