Objective:To explore the factors and predictive nursing measures that induce psychological symptoms in patients undergoing cardiac and vascular surgery.Method:A total of 60 cases from hospital were randomly divided into a control group of 30 cases receiving routine care, and an observation group of 30 cases receiving predictive care to analyze the risk factors for inducing psychiatric symptoms.Result:After observing the incidence of mental disorders at 24 hours, 72 hours, and 1 week after surgery in the observation group, they were all at lower levels compared to the control group (P<0.05). After intervention, both groups showed a decrease in their mental symptoms and an increase in their daily living abilities, with the observation group being more prominent (P<0.05). The observation group had a lower level of negative grouping after intervention (P<0.05). The observation group had higher levels of self-management ability and quality of life (P<0.05). Conclusion:Intervention targeting the influencing factors of postoperative mental symptoms in patients undergoing cardiac and vascular surgery can reduce the rate of mental disorders, improve mental symptoms and daily living activities, alleviate negative emotions, improve self-care ability, and enhance quality of life.