Heavy metals are widely used in agriculture, industry and medical industry, such as the production of insecticides, batteries, alloys, textile dyes and drugs. Long-term, high-intensity or excessive exposure to heavy metals can induce related systemic diseases. The kidney has the functions of filtration, reabsorption and concentration, and is an important target organ for heavy metal toxicity. The degree and manifestation of renal injury depend on the type, dose and exposure time of heavy metals. Heavy metal-induced renal injury not only brings heavy burden to society and family, but also often endangers the life and health of patients. Because the pathogenic mechanisms of renal injury caused by different heavy metals are different, the difficulty of treatment is increased. By discussing the recent research results of several common heavy metal renal injury mechanisms at home and abroad, we can provide a basis for clinical treatment and research.
heavy metalskidney injuryoxidative stressmitochondrial damageautophagy
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