Objective:To investigate the relationship between the degree of exophthalmos and brain natriuretic peptide in patients with hyperthyroidism(hyperthyroidism).Methods:A total of 60 patients with hyperthyroidism and exophthalmoism admitted to hospital were enrolled as the study subjects.According to the degree of hyperthyroidism,the degree of hyperthyroidism was divided into mild exophthalmos(19～20 mm)group,moderate exophthalmos(21～23 mm)group,and severe exophthalmos(＞23 mm)group,with 20 cases in each group,and serum brain natriuretic peptide and thyroid hormone were compared in the three groups,and the influencing factors of hyperthyroidism were analyzed.Results:The levels of natriuretic peptide in the moderate and severe exophthalmos groups were higher than those in the mild exophthalmos group,and the levels of brain natriureate peptide in the severe exophthalmos group were higher than those in the moderate exophthalmos group,and the three groups were statistically significant(P＜0.05).The levels of free triiodothyronine(FT3)and serum free thyroxine(FT4)in the moderate and severe exophthalmos groups were higher than those in the mild exophthalmos group,and the levels of severe exophthalmos were higher than those in the moderate exophthalmos group,and the three groups were statistically significant(P＜0.05).Ordinal logistic regression analysis showed that elevated natriuretic peptide level was an independent risk factor for patients with hyperthyroidism(P＜0.05).Conclusion:The more severe the exophthalmos,the higher the levels of natriuretic peptide and thyroid hormone in patients with hyperthyroidism,so monitoring the level of natriuretic peptide is beneficial to the prevention and treatment of hyperthyroidism.
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