首页|贝伐珠单抗联合免疫治疗对非鳞非小细胞肺癌的效果分析

贝伐珠单抗联合免疫治疗对非鳞非小细胞肺癌的效果分析

Effect analysis of combined immunotherapy with bevacizumab in patients with non-squamous non-small cell lung cancer

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目的:探讨非鳞非小细胞肺癌患者临床治疗中贝伐珠单抗、免疫治疗联合应用效果.方法:选取医院收治的60例非鳞非小细胞肺癌患者,采取随机数表法将其分为两组,每组30例患者,对照组患者给予免疫治疗(替雷利珠单抗、卡瑞利珠单抗或信迪利单抗),观察组患者应用抗血管生成治疗(贝伐珠单抗)联合免疫治疗,分析患者临床效果、肿瘤标志物水平、不良反应.结果:观察组患者治疗后肿瘤标志物含量低于对照组(P<0.05);观察组患者的治疗总有效率明显高于对照组(P<0.05);两组患者不良反应发生率无明显差异(P>0.05).结论:贝伐珠单抗与免疫治疗联合应用对非鳞非小细胞肺癌病情具有良好的改善作用,且副作用可以耐受,值得临床应用及推广.
Objective:To analyze the effect of combination of bevacizumab and immunotherapy in the clinical treatment of patients with non-squamous non-small cell lung cancer.How:A total of 60 patients with non-squamous non-small cell lung cancer admitted to hospital were selected and divided into 2 groups with 30 patients in each group by random number table method.Immunotherapy(tirellizumab,carrilizumab or sindillizumab)and anti-angiogenic therapy(bevacizumab)were given,respectively.Clinical effects,tumor marker levels and adverse reactions were analyzed.Results:The total effective rate of observation group was significantly higher than that of control group(P<0.05).After treatment,the tumor marker content in observation group was better than that in control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of bevacizumab and immunotherapy has a good effect on the improvement of non-squamous non-small cell lung cancer and the side effects can be tolerated,which is worthy of widespread clinical promotion and application.

bevacizumabimmunotherapyantiangiogenic therapynon-squamous non-small cell lung cancer

曹怀刚、杜凯

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定远县总医院肿瘤内科 安徽定远 233200

滁州市第一人民医院 安徽滁州 239004

贝伐珠单抗 免疫治疗 抗血管生成治疗 非鳞非小细胞肺癌

安徽省自然科学基金(2022)

AH2022ky8521

2024

安徽医专学报
安徽医学高等专科学校

安徽医专学报

影响因子:0.441
ISSN:2097-0196
年,卷(期):2024.23(2)
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