Objective:To explore the diagnostic value of combined use of protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),alpha-fetoprotein(AFP),γ-glutamyl transpeptidase(GGT)and alkaline phosphatase(ALP)in primary hepatic carcinoma(PHC).Methods:41 patients with initial PHC were selected as PHC group,39 patients with liver cirrhosis as cirrhosis group,and 40 healthy physical examination subjects as healthy control group.The levels of serum PIVKA-Ⅱ,AFP,GGT and ALP in each group were quantitatively detected and compared among the groups.The sensitivity,specificity and area under the curve(AUC)of each index alone and in combination were analyzed,and the receiver operating characteristic curve(ROC)was plotted.Results:The serum levels of PIVKA-Ⅱ,AFP,GGT and ALP in PHC group were higher than those in cirrhosis group and healthy control group(P＜0.05);The AUC of PIVKA-Ⅱ,AFP,GGT and ALP were 0.839,0.834,0.837 and 0.799,respectively.The AUC of combined detection was higher than that of each index alone.The AUC and the sensitivity of combined detection of PIVKA-Ⅱ,AFP,GGT and ALP were highest(0.939,90.24%),and the specificity of combined detection of PIVKA-Ⅱ and AFP was highest among all the detection groups(97.47%).Conclusions:The combined detection of serum PIVKA-Ⅱ,AFP,GGT and ALP can improve the diagnostic efficiency of PHC,and the combination of the four is beneficial to the early screening and diagnosis of PHC.
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