Objective:To investigate the bone mineral density(BMD)in children with short stature and analyze the correlation between baseline BMD and 25 hydroxyvitamin D.Methods:The BMD of 88 children with short stature was compared with that of 88 children with normal height.The correlation between BMD and 25 hydroxyvitamin D of observation group was analyzed.The observation group was classified according to growth hormone deficiency,puberty or not and vitamin D nutritional status,and the bone mineral density of different states was compared respectively.Results:The bone mineral density Z-score of observation group was lower than that of control group(P=0.004).There was no correlation between baseline bone mineral density Z-score and 25 hydroxyvitamin D in children with nanosomia was found(r=0.007,P=0.947).The bone mineral density Z-score of the growth hormone deficiency group was lower than that of the idiopathic short stature group,but the difference was not statistically significant(P=0.321).The bone mineral density Z-score of the adolescent group was lower than that of the preadolescent group,and the difference was statistically significant(P=0.001).BMD Z-score was negatively correlated with age and bone age(r=-0.579,-0.573,P＜0.001),but no correction with 25-hydroxyvitamin D was discovered(P=0.436).Conclusion:The bone mineral density Z-score in children with nanosomia was lower than that in children with normal height,especially in those with pubertal development.Baseline 25 hydroxyvitamin D does not illustrate BMD level in children with nanosomia,and the time cumulative effect of insufficient bone mass accumulation should be considered.
short staturechildrenbone mineral densityvitamin Dgrowth hormone deficiency
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NSTL
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