矮小症儿童骨密度与25羟维生素D相关性分析
Analysis of the correlation between bone mineral density and 25 hydroxyvitamin D in children with short stature
石淑霞 1彭武2
作者信息
- 1. 安徽医学高等专科学校临床医学院 安徽合肥 230601
- 2. 安徽医科大学第二附属医院儿科 安徽合肥 230601
- 折叠
摘要
目的:探讨矮小症儿童的骨密度,分析骨密度与25羟维生素D的相关性.方法:将88例矮小症儿童列为观察组,与88例身高正常儿童的骨密度比较;分析观察组骨密度与25羟维生素D的相关性.根据是否生长激素缺乏、是否青春发育、维生素D营养状态将观察组进行分类,比较各类状态的骨密度.结果:观察组儿童的骨密度Z值低于对照组(P=0.004).矮小症儿童基线骨密度Z值与25羟维生素D无相关性(r=0.007,P=0.947).生长激素缺乏症组的骨密度Z值低于特发性矮身材组,但差异无统计学意义(P=0.321).青春期组儿童的骨密度Z值低于青春期前组,差异有统计学意义(P=0.001).维生素D不足组的矮小儿童骨密度与年龄、骨龄呈负相关(r=-0.579、-0.573,P＜0.001),与25羟维生素D无相关性(P=0.436).结论:矮小症儿童骨密度Z值低于身高正常儿童,青春发育者尤明显;25羟维生素D值不能反映矮小症儿童的骨密度水平,骨量积累不足需考虑时间累积效应.
Abstract
Objective:To investigate the bone mineral density(BMD)in children with short stature and analyze the correlation between baseline BMD and 25 hydroxyvitamin D.Methods:The BMD of 88 children with short stature was compared with that of 88 children with normal height.The correlation between BMD and 25 hydroxyvitamin D of observation group was analyzed.The observation group was classified according to growth hormone deficiency,puberty or not and vitamin D nutritional status,and the bone mineral density of different states was compared respectively.Results:The bone mineral density Z-score of observation group was lower than that of control group(P=0.004).There was no correlation between baseline bone mineral density Z-score and 25 hydroxyvitamin D in children with nanosomia was found(r=0.007,P=0.947).The bone mineral density Z-score of the growth hormone deficiency group was lower than that of the idiopathic short stature group,but the difference was not statistically significant(P=0.321).The bone mineral density Z-score of the adolescent group was lower than that of the preadolescent group,and the difference was statistically significant(P=0.001).BMD Z-score was negatively correlated with age and bone age(r=-0.579,-0.573,P＜0.001),but no correction with 25-hydroxyvitamin D was discovered(P=0.436).Conclusion:The bone mineral density Z-score in children with nanosomia was lower than that in children with normal height,especially in those with pubertal development.Baseline 25 hydroxyvitamin D does not illustrate BMD level in children with nanosomia,and the time cumulative effect of insufficient bone mass accumulation should be considered.
关键词
矮小症/儿童/骨密度/25羟维生素D/生长激素缺乏症Key words
short stature/children/bone mineral density/vitamin D/growth hormone deficiency引用本文复制引用
基金项目
安徽省高校优秀青年人才支持计划项目(gxyq2019191)
出版年
2024
NETL
NSTL
万方数据