Objective:Prolonged inflammatory bowel disease(IBD)is prone to malignant transformation,which can lead to colorectal cancer(CRC),and there is still a lack of effective treatment for IBD in the clinic.Recent studies have shown that human umbilical cord mesenchymal stem cells(hucMSCs)and their derived exosomes(Exs)can repair DSS induced mouse IBD,and human umbilical cord mesenchymal stem cell derived exosomes(hucMSC-Exs)inhibit AOM/DSS induced malignant transformation of mouse IBD,possibly by downregulating the expression of small ubiquitin-like modifier-1(SUMO 1)and affecting the regulation of related signaling pathways.However,the exact mechanism needs to be elucidated.This article attempts to elucidate the target cells of colorectal mucosal tissue affected by hucMSC-Exs and their response to hucMSC-Exs,reveal the key molecules and related signaling pathways that downregulate SUMO1 expression in target cells by hucMSC-Exs,and deeply explore the mechanism of hucMSC-Exs inhibiting IBD malignant transformation,providing new ideas and experimental basis for hucMSC-Exs treatment of IBD and its malignant transformation.
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