Objective:To investigate the effect of ultrasound stellate ganglion block (SGB) combined with nalbuphine on the postoperative condition of patients undergoing laparoscopic cholecystectomy (LC).Methods:LC patients were divided into the control group and the combined group,with 50 patients in each group.Patients in the combined group were given 0.25% ropivacaine 5 mL for 10 min before induction of general anesthesia on the basis of the control group to perform ultrasound-guided SGB.Compare the effects of two groups of patients.Results:Compared with the control group,the mean arterial pressure and heart rate at all time periods,postoperative VAS pain score,the incidence rate of PONV grade 2-4 and the use rate of antiemetic drugs were decreased,while the incidence rate of PONV grade 0-1 was significantly increased in the combined group (P<0.05).The differences in mean arterial pressure and heart rate at T0,operative time,and awakening time between the two groups were not statistically significant (P>0.05).Conclusions:SGB combined with nalbuphine attenuates intraoperative hemodynamic fluctuations and reduces the incidence of postoperative pain and nausea and vomiting in LC patients.