摘要
目的:探讨上消化道出血患者采用奥曲肽联合奥美拉唑治疗对提高止血效果、改善炎症因子的影响.方法:选取在医院接受药物治疗的70例上消化道出血患者,将其中35例采用奥曲肽联合奥美拉唑治疗的患者设为试验组,另外35例仅采用奥美拉唑单独治疗的患者设为参照组,对比分析两组治疗效果、止血时间、住院时间、平均出血量、不良反应发生率及炎症水平改善情况.结果:试验组患者止血总有效率高于参照组(P<0.05),止血时间、住院时间明显短于参照组(P<0.05),平均出血量低于参照组(P<0.05),TNF-α、CRP、IL-6等炎症水平改善情况明显优于参照组(P<0.05);两组患者恶心呕吐、头晕头痛等不良反应发生率差异无统计学意义(P>0.05).结论:奥曲肽联合奥美拉唑治疗上消化道出血具有良好的效果,不仅有利于提升止血的效果,同时也更有利于缩短止血时间,且不会明显增加不良反应.
Abstract
Objective:To analyze the effect of octreotide combined with omeprazole on improving hemostasis and inflammatory factors in patients with upper gastrointestinal bleeding.Methods:A total of 70 patients with upper gastrointestinal bleeding who received drug treatment in hospital were selected,35 of whom were treated with octreotide combined with omeprazole as the experimental group,and 35 of whom were treated with omeprazole alone as the reference group.The therapeutic effect,hemostatic time,hospital stay,average blood loss,incidence of adverse reactions and improvement of inflammation level were compared between the two groups.Result:The total hemostatic effective rate of experimental group was significantly higher than that of the reference group (P<0.05),the hemostatic time and hospital stay were significantly shorter than that of the reference group (P<0.05),the average blood loss was significantly lower than that of the reference group (P<0.05),and the improvement of TNF-α,CRP,IL-6 and other inflammation levels was significantly better than that of the reference group (P<0.05).There was no statistically significant difference in the incidence of adverse reactions such as nausea,vomiting,dizziness,and headache between two groups of patients (P>0.05).Conclusion:Octreotide combined with omeprazole has good results on upper gastrointestinal bleeding,which not only improves the effect of hemostasis,but also shortens the time of hemostasis,and does not significantly increase the adverse reactions.
基金项目
2022年度安徽省自然科学基金项目(AH2022kj8762)
维普
万方数据