Objective:To analyze the influencing factors of psychological distress in end-stage renal failure hemodialysis patients.Method:81 end-stage renal failure hemodialysis patients admitted to hospital were selected.The psychological distress status was evaluated using a psychological distress thermometer (DT),and the influencing factors were analyzed through linear regression.The DT score of 81 patients was (4.35±1.04),indicating moderate pain level;The Social Impact Scale (SIS) score is (41.36±5.19).Comparison of DT scores among patients with different educational levels,dialysis duration,and hope level data (P<0.05).According to Pearson's test,there is a positive correlation between shame and psychological pain (r=5.106,P<0.05);linear regression analysis results show that education level of junior high school or below,dialysis time≥ 1 year,low hope level,and heavy shame are all influencing factors of psychological pain (P<0.05).Conclusion:The psychological distress of end-stage renal failure hemodialysis patients is influenced by factors such as educational level,dialysis duration,hope level,and disease shame.