Objective:To evaluate the prognostic value and clinical significance of the combined assessment of hemoglobin,albumin,lymphocytes,and platelets(HALP)score with blood urea nitrogen(BUN)in predicting the outcomes of patients with large-area burns.Methods:A total of 112 patients with large-area burns were included in the study.Based on the 90-day post-injury survival outcome,patients were categorized into a survival group(n=96)and a death group(n=16).Clinical data,including age,gender,length of hospital stay,and laboratory indicators(albumin,platelets,BUN,and hemoglobin)measured on the third day post-admission,were collected.Univariate and multivariate logistic regression analyses were performed to identify the prognostic factors.The predictive accuracy of the HALP score,BUN,and their combined use was assessed through receiver operating characteristic(ROC)curve analysis.Results:The HALP score and BUN levels in the death group were significantly higher than those in the survival group(P<0.05).ROC curve analysis revealed that the AUC values for the HALP score,BUN,and their combination were 0.779,0.757,and 0.874,respectively.Conclusion:The HALP score and BUN are reliable indicators for predicting the prognosis of patients with large-area burns,and their combined use offers superior predictive performance.