首页|冠状动脉介入术对维持性血液透析合并冠心病患者的影响研究

冠状动脉介入术对维持性血液透析合并冠心病患者的影响研究

Clinical application of coronary interventional therapy in maintenance hemodialysis patients with coronary heart disease

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目的:探讨维持性血液透析患者合并冠心病患者接受冠状动脉介入手术的临床疗效.方法:选取在医院接受治疗的70例慢性肾功能衰竭并行持续血液透析且伴有冠心病患者,以前瞻性随机数表法划分为对照组和研究组各35例.对照组给予传统药物治疗,研究组则接受冠状动脉介入手术.对两组患者的心功能指标、血清氨基末端B型脑钠肽前体(NT-proBNP)、炎症因子、肾功能指标及心血管事件发生率进行对比.结果:治疗后,研究组患者LVEF水平均高于对照组,而LVEDV水平低于对照组(P<0.05).研究组患者IL-10水平高于治疗前,而NT-proBNP、IL-1、TNF-α水平均低于对照组(P<0.05).治疗前后,两组患者肾功能指标水平比较,差异均无统计学意义(P>0.05).结论:对于慢性肾功能衰竭并行持续血液透析且伴有冠心病患者,冠状动脉介入手术能明显提升临床疗效,有效调整炎症因子及NT-proBNP水平,改善心功能,并具有较高的安全性.
Objective:To evaluate the therapeutic impact of coronary intervention on hemodialysis patients suffering from coronary heart disease.Methods:A total of 70 individuals with chronic renal failure,undergoing regular hemodialysis,and diagnosed with coronary heart disease were randomly allocated into two groups,each comprising 35 participants.The control group received conventional medication,whereas the study group was subjected to coronary intervention.Key outcomes,including cardiac function parameters,serum NT-proBNP,inflammatory markers,renal function indicators,and the frequency of cardiovascular events,were compared between the two groups.Results:Post-treatment,the study group exhibited significantly higher LVEF values and lower LVEDV values compared to the control group(P<0.05).Additionally,the study group showed elevated IL-10 levels and reduced NT-proBNP,IL-1,and TNF-α levels relative to the control group(P<0.05).No significant changes in renal function parameters were observed between the two groups before and after treatment(P>0.05).Conclusion:For patients with chronic renal failure,continuous hemodialysis,and coronary heart disease,coronary intervention demonstrates superior clinical outcomes,enhances cardiac performance,and effectively modulates inflammatory markers and NT-proBNP levels,while maintaining high safety.

coronary artery interventionmaintenance hemodialysischronic kidney failurecoronary heart disease

刘杨艳、刘李林、骆静

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南京医科大学第二附属医院肾脏病中心 江苏 南京 210003

冠状动脉介入 维持性血液透析 慢性肾衰竭 冠心病

2024

安徽医专学报
安徽医学高等专科学校

安徽医专学报

影响因子:0.441
ISSN:2097-0196
年,卷(期):2024.23(6)