摘要
目的:探讨细胞学现场快速评价(C-ROSE)联合经支气管镜活检术在肺占位性病变诊断中的应用价值.方法:选择医院收治的88例肺占位性病变患者进行C-ROSE、经支气管镜活检术检查,分析C-ROSE联合经支气管镜活检术在肺占位性病变诊断中的应用价值.结果:在88例肺占位性病变患者中,病理科专家判读的结果显示恶性病变为39例,占44.32%(39/88),良性病变为49例,占55.68%(49/88).C-ROSE联合经支气管镜活检术及两者单独诊断与病理学家独立判读肺占位性病变结果的一致性Kappa值分别为0.954、0.747、0.788.C-ROSE联合经支气管镜活检术在肺占位性病变诊断中的灵敏度为97.44%(38/39)、特异度为97.96%(48/49)、准确度为97.73%(86/88),均高于单独诊断,差异有统计学意义(P＜0.05).绘制ROC曲线,结果显示,C-ROSE、经支气管镜活检术、C-ROSE联合经支气管镜活检术在肺占位性病变诊断中的AUC值为0.749、0.769、0.954,联合诊断的价值更高.结论:C-ROSE联合经支气管镜活检术在肺占位性病变的诊断中具有显著的应用价值,其灵敏度、特异度和准确度均明显优于单独使用C-ROSE或经支气管镜活检术.
Abstract
Objective:To explore the application value of rapid on-site evaluation of cytology(C-ROSE)combined with bronchoscopy biopsy in the diagnosis of lung space occupying lesions.Method:88 patients with lung space occupying lesions in hospital were selected for C-ROSE and bronchoscopy biopsy examination.The results independently interpreted by pathologists were used as the gold standard to analyze the application value of C-ROSE combined with bronchoscopy biopsy in the diagnosis of lung space occupying lesions.Among the 88 patients with lung space occupying lesions,pathologists independently identified 39 cases as malignant lesions,accounting for 44.32%(39/88),and 49 cases as benign lesions,accounting for 55.68%(49/88).The consistency Kappa values of C-ROSE combined with bronchoscopy biopsy and the independent diagnosis of lung space occupying lesions by pathologists were 0.954,0.747,and 0.788,respectively.The sensitivity,specificity,and accuracy of C-ROSE combined with bronchoscopy biopsy in the diagnosis of lung space occupying lesions were 97.44%(38/39),97.96%(48/49),and 97.73%(86/88),all higher than those of single diagnosis,with statistical differences(P＜0.05).Draw ROC curves,and the results show that the AUC values of C-ROSE,transbronchial biopsy,and C-ROSE combined with transbronchial biopsy in the diagnosis of lung space occupying lesions are 0.749,0.769,and 0.954,respectively.The value of combined diagnosis is higher.Conclusion:The combination of C-ROSE and bronchoscopic biopsy has significant application value in the diagnosis of lung space occupying lesions,and its sensitivity,specificity,and accuracy are significantly better than using C-ROSE alone or bronchoscopic biopsy.
维普
万方数据