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高尿酸血症与认知的研究进展(综述)

Research advances in hyperuricemia and cognition

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随着高尿酸血症的发病率呈逐年上升的趋势,血尿酸水平除了影响内分泌疾病、心血管疾病、慢性肾脏病以外,与神经退行性疾病也有密切的关系,可能导致认知功能障碍.近年来有很多试验研究探讨高尿酸血症与认知功能的关系,但始终没有确切的证据证实尿酸对认知影响的利与弊.该文就尿酸影响认知的可能机制以及作用结果的相关研究进行综述.
Hyperuricemia is prevailing in modern society,and its incidence has been on the rise.Studies have found that the level of serum uric acid is not only related to endocrine diseases,but also involved in cardiovascular diseases,chronic kidney disease,and even has a certain diagnostic value for neurodegenerative diseases,which can lead to cognitive dysfunction.In recent years,many clinical and experimental studies have shown the relationship between hyperuricemia and cognitive function,but there is no conclusive evidence to confirm its effects on cognition.This paper summarized the current researches on the possible role of uric acid in cognitive function.

serum uric acidcognitionoxidative stressinflammation

张雅琪、王林、肖融、何健乐、高晓蔓、唐优、邓大同

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安徽医科大学第一附属医院内分泌科 安徽 合肥 230022

安徽医科大学第一附属医院全科医学科 安徽 合肥 230022

尿酸 认知 氧化应激 炎症

2024

安徽医专学报
安徽医学高等专科学校

安徽医专学报

影响因子:0.441
ISSN:2097-0196
年,卷(期):2024.23(6)