The anti-inflammatory effect of triterpene acids of loquat leaf
Objective To study the anti-inflammatory effect of triterpene acids of loquat leaf (TAL). Methods To explore the anti-inflammatory actions of TAL, acute inflammatory models including mice ear edema, mice celiac capillary permeation, and rat palm swelling induced by dimethylbenzene, acetic,and carrageenin respectively and chronic inflammatory models including granulation hyperplasia and adjuvant arthritis ( AA) caused by the implantation of cotton pill and freund's complete adjuvant( FCA) in rats respectively were used. Results TAL (75, 225, 675 mg/kg, ig) could significantly inhibit the ear edema and celiac capillary permeation in mice; TAL (50, 150, 450 mg/kg , ig) could not only inhibit the paw swelling, granulation hyperplasia in rats, but also attenuate the primary and secondary inflammatory reaction, reduce the multiple arthritis score, and inhibit the hind-paw pathological changes in A A rats. TAL(0. 05, 0. 5, 5, 50 mg/L) could not only increase splenocytes proliferation and IL-2 production of splenocytes induced by ConA and LPS, but also reduce the elevated IL-1 production from peritoneal macrophage (PMΦ) in AA rats in vitro. Conclusion TAL has a remarkable anti-inflammatory effect.
triterpenes/pharmacologyinflammation/zhong yao liao fafolium eriobotryae/ pharmacologyfolium erio-botryae/chemistry
国家科技期刊平台
NSTL
万方数据
维普
