Early clinical effect of intra-arterial induction chemotherapy on Locally advanced nasopharyngeal carcinoma
LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P <0.05),and at 12 weeks,98.0% vs 72.0%,with statistical significance (P <0.05).The effective rate of the two groups was both 100%,and there was no distant metastasis.3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32.0% and 34.0%,respectively,without statistical significance (P >0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely.