首页|动脉灌注化疗对局部晚期鼻咽癌的近期疗效

动脉灌注化疗对局部晚期鼻咽癌的近期疗效

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将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗(IAC)组和静脉诱导化疗联合放疗(IVC)组。治疗后4周, IAC 组与 IVC 组的完全缓解(CR)率分别为94.0%、70.0%,差异有统计学意义(P <0.05);治疗后12周,IAC 组与 IVC组的 CR 率分别为98.0%、72.0%,差异有统计学意义(P <0.05)。两组治疗有效率均为100%,均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较,差异无统计学意义(P >0.05)。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。
Early clinical effect of intra-arterial induction chemotherapy on Locally advanced nasopharyngeal carcinoma
LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P <0.05),and at 12 weeks,98.0% vs 72.0%,with statistical significance (P <0.05).The effective rate of the two groups was both 100%,and there was no distant metastasis.3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32.0% and 34.0%,respectively,without statistical significance (P >0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely.

intra-arterial chemotherapyradio-chemotherapylocally advanced nasopharyngeal carcinomaearly clinical effect

陈建武、张幸平、刘德鑫、肖丽华、吴敏、苏菁菁、郑建清

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福建医科大学附属第二医院放疗科,泉州 362000

重庆医科大学附属第一医院肿瘤科,重庆 400016

福建医科大学附属第二医院放射科,泉州 362000

动脉灌注 放化疗 局部晚期鼻咽癌 近期疗效

福建省自然科学基金福建省医学创新课题

2011J011552009cx-10

2015

安徽医科大学学报
安徽医科大学

安徽医科大学学报

CSTPCD北大核心
影响因子:1.095
ISSN:1000-1492
年,卷(期):2015.(11)
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