Objective To develop a high modulus and high strength biodegradable silk fibroin GBR membrane to address the issue of maintaining the space for bone regeneration in the repair of osseous defects.Methods After purifying silk fibroin protein,membrane materials were prepared using evaporation-hot pressing method.The physi-cal and chemical properties and biological performance of the membranes were evaluated using stretching tests,in vitro simulations,and cell co-culturing methods.Results A silk fibroin GBR membrane was successfully fabrica-ted,resulting in a simulated degradation rate of 35.3%after 12 h in vitro.The wet-state elastic modulus reached 45 MPa,while the tensile strength reached 8.39 MPa.Furthermore,the cell survival rate was nearly 100%after 7 days.Conclusion The biodegradable GBR membrane produced in this study possesses high modulus and strength,as well as excellent biocompatibility,offering a promise as a foundation for addressing the bone defect re-pair and bone space maintenance.
关键词
骨缺损修复/成骨空间维持/引导骨再生膜/丝素蛋白/蒸发-热压法/成骨分化/拉伸强度
Key words
bone defect repair/maintaining the space for bone regeneration/guided bone regeneration mem-brane/silk fibroin/evaporation-heat pressing method/osteogenic differentiation/tensile strength
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