摘要
目的 探讨18F-FDG PET/CT动态成像诊断原发性肝癌与肝转移瘤中的应用价值.方法 该研究以通过全身动态18 F-FDG PET/CT成像的94例肝脏恶性病变[肝细胞癌组(25例)、胆管细胞癌组(27例)、肝转移瘤组(42例)]的患者资料作为研究对象,应用单因素方差分析(ANOVA)、受试者工作特征曲线(ROC)等方法对不同病理类型肝恶性肿瘤患者的:病灶最大标准化摄取值(SUVmax)、FDG代谢率(MRFDG)、靶-本底比值(TBR)和病灶的最大直径(dmax)等影像学特征进行统计学分析.结果 在94例患者中,肝细胞癌组、胆管细胞癌组和肝转移瘤组的SUVmax、MRFDG、TBRSUVmax和TBRMRFDG差异均有统计学意义(SUVmax:F=48.773,P<0.001;MRFDG:F=26.334,P<0.001;TBRSUVmax:F=41.314,P<0.001;TBRMRFDG:F=20.821,P<0.001).SUVmax、MRFDG、TBRSUVmax和TBRMRFDG鉴别诊断原发性肝癌与肝转移瘤的AUC分别为0.836、0.851、0.827和0.847.SUVmax、MRFDG与肝脏恶性肿瘤病灶的最大直径dmax之间存在正相关(SUVmax:r=0.4,P<0.05;MRFDG:r=0.2,P<0.05),差异有统计学意义.结论 18F-FDG PET/CT动态成像在不同病理类型肝脏恶性肿瘤中有较好的鉴别诊断效能.不同病理类型肝脏恶性肿瘤SUVmax、MRFDG和病灶的最大直径dmax之间存在一定正相关关系.
Abstract
Objective To explore the value of 18F-FDG PET/CT dynamic imaging in the diagnosis of primary liver cancer and liver metastases.Methods In this study, the data of 94 patients with hepatic malignant lesions [hepa-tocellular carcinoma group (25 cases) , cholangiocellular carcinoma group (27 cases) , and liver metastases group (42 cases) ] imaged by whole-body dynamic 18 F-FDG PET/CT were used as the research subjects, and the meth-ods of (ANOVA) and subjects' working characteristic curves (ROC) were applied to examine the patients with liv-er malignant tumours of different pathological types SUVmax, MRFDG, TBR and dmax were statistically analysed as im-aging features.Results Among 94 patients, the differences in SUVmax, MRFDG, TBRSUVmax and TBRMRFDG were sta-tistically significant in the hepatocellular carcinoma, cholangiocellular carcinoma and hepatic metastasis groups (SUVmax: F =48.773, P <0.001; MRFDG: F =26.334, P <0.001; TBRSUVmax: F =41.314, P <0.001;TBRMRFDG:F=20.821, P<0.001).The AUCs for the differential diagnosis of primary hepatocellular carcinoma and hepatic metastases for SUVmax, MRFDG, TBRSUVmax, and TBRMRFDG were 0.836, 0.851, 0.827, and 0.847, re-spectively.There was a positive correlation between SUVmax, MRFDG, and the hepatic malignant lesions' There was a positive correlation between SUVmax, MRFDG and the maximum diameter dmax(SUVmax:r=0.4, P<0.05;MRFDG:r=0.2, P<0.05), and the difference was statistically significant.Conclusion 18F-FDG PET/CT dynamic ima-ging has good differential diagnostic efficacy in different pathological types of liver malignant tumors.There is a pos-itive correlation between SUVmax, MRFDG and dmax in different pathological types of liver malignant tumors.
基金项目
国家自然科学基金(81801736)
安徽省自然科学基金(2108085QH355)
安徽省高等学校科学研究基金(2022AH051165)
安徽医科大学第一附属医院青年培养项目(2021kj05)
国家科技期刊平台
NSTL
万方数据