Effect of highly purified hMG on ovulation induction in normal ovarian responder patients with antagonist protocol
Objective To compare the differences in clinical outcomes of ovulation induction with highly purified human menopausal gonadotropin(HP-hMG,Menopur)versus recombinant human follicle stimulating hormone(rFSH,Gonal-F)in normal ovarian responder patients treated with the GnRH-antagonist protocol.Methods Pa-tients treated with the GnRH-antagonist protocol were retrospectively analyzed and divided by gonadotropin(Gn)usage into HP-hMG group and rFSH group.The basic characteristics,ovulation induction method,laboratory inde-xes,and clinical outcomes were compared between the two groups.Results A total of 614 normal ovarian re-sponder patients were enrolled in the study,with 216 in the HP-hMG group and 398 in the rFSH group.There was no significant difference in P levels and LH levels on the hCG trigger day between the two groups.However,the E2 levels on the hCG trigger day were significantly lower in the HP-hMG group(P＜0.001).Moreover,the HP-hMG group had a higher biochemical pregnancy rate(69.23％vs 63.51％)and clinical pregnancy rate(66.67％vs 59.46％)compared to the rFSH group.The incidence of OHSS in the HP-hMG group(2.31％vs 3.02％)showed a decreasing trend compared to the rFSH group.Conclusion Compared to rFSH,HP-hMG offers distinct advanta-ges in reducing the incidence of OHSS and improving pregnancy outcomes in normal ovarian responder patients un-dergoing pituitary suppression with the GnRH-antagonist protocol.
normal ovarian responderHP-hMGrFSHin vitro fertilization-embryo transfercontrolled ovulation induction
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