Intestinal flora and risk of acute myeloid leukemia:a two-sample bidirectional mendelian randomization study
Objective To explore the causal relationship between the abundance of intestinal flora(IF)and the risk of developing acute myeloid leukemia(AML)using two-sample bidirectional Mendelian randomization(MR)methods.Methods The MiBioGen Consortium and FinnGen databases were utilized for the IF abundance and AML genome-wide association datasets,respectively.The primary analysis method entailed variance inverse weigh-ting,supplemented by weighted median test,while heterogeneity was assessed using Cochran's Q test.Additional-ly,MR-PRESSO was employed to identify any outliers,while MR-Egger intercept was utilized to evaluate horizontal pleotropy.Results Higher abundance of genetically determined Dialister(P=0.034,OR=4.373,95％CI:1.329-14.392),Veillonaceae(P=0.009,OR=2.029,95％CI:1.839-3.866),and Lachnospiraceae UCG008(P=0.034,OR=3.827,95％CI:1.107-13.228)were found to be linked to an increased risk of AML.In contrast,Ruminococcaceae(P=0.042,OR=0.176,95％CI:0.033-0.939)and Peptococcaceae(P=0.025,OR=0.168,95％CI:0.035-0.803)were associated with a reduced risk of this disease.Conclusion Higher levels of the Dialister,the Veillonellaceae,and the Lachnospiraceae UCG008 are risk factors for AML,while the families Ruminococcaceae and Peptococcaceae are identified as protective factors against AML.
万方数据
维普
