首页|循环肿瘤细胞在胰腺癌早期诊断及预后中的研究进展

循环肿瘤细胞在胰腺癌早期诊断及预后中的研究进展

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胰腺癌是一类恶性程度高、预后极差的消化道恶性肿瘤,早期诊断困难,而可靠的生物标志物的应用将有利于胰腺癌的早期评估和管理。循环肿瘤细胞(CTCs)被排入血液中,可以相对容易地从微创的液基活检中被获得并用于检测,从而在早期肿瘤诊断、肿瘤预后和治疗反应监测等方面发挥应用潜力。本文对国内外近十年来检测CTCs的技术进展及CTCs在胰腺癌中多方面的临床应用进行综述,以期为胰腺癌的早期诊断及预后提供新视角。
Research progress on circulating tumor cells for early diagnosis and prognosis of pancreatic cancer
Pancreatic cancer is a highly malignant gastrointestinal cancer with a poor prognosis,and early diagnosis remains challenging.The use of reliable biomarkers can significantly enhance the early evaluation and management of this disease.Circulating tumor cells(CTCs)are released into the bloodstream and can be obtained easily through minimally invasive liquid-based biopsy,making them promising candidates for early tumor diagnosis,prognosis assessment,and monitoring therapeutic responses.This paper reviews the advancements in CTCs detec-tion technology and their clinical applications in pancreatic cancer over the past decade,both domestically and in-ternationally,which offer a new perspective on the early diagnosis and prognosis of pancreatic cancer.

circulating tumor cellspancreatic cancerliquid-based biopsybiomarkers

蒋梦若、彭立嗣、夏传超、李诗钰

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海军军医大学附属长海医院消化内科,上海 200433

浙江大学医学院附属第一医院消化内科,杭州 310002

循环肿瘤细胞 胰腺癌 液基活检 生物标志物

2024

安徽医科大学学报
安徽医科大学

安徽医科大学学报

CSTPCD北大核心
影响因子:1.095
ISSN:1000-1492
年,卷(期):2024.59(11)