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论"态靶结合"辨治方略在糖尿病性黄斑水肿中的应用

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"态靶辨治"是中科院院士仝小林提出的一种延续传统中医辨证论治并契合现代医学诊疗思维而创新的临床辨治新思想,它揭示了中医"态"的本质和调态的机制,使疾病视角更加立体,并充分利用中药现代药理研究成果,发挥中医药多靶点治疗优势,使用药更加精准、治疗更加对症.糖尿病性黄斑水肿是引起工龄人群中心视力下降的主要原因之一,临床上西医治疗手段致其复发率高、控制率欠佳,针对这种情况,运用态靶学术思想,从宏观角度识疾病异时之态,微观角度精准定靶,调态打靶,重新构建疾病诊疗体系,旨在提高临床疗效.作者通过学习仝小林院士"态靶结合"辨治方略内涵,结合我们团队治疗糖尿病性黄斑水肿的临床实践,辨该病以"瘀"态为因为本,以"损"态为果为标,审前因,善后果,从宏观调瘀态,微观调损态,结合病靶、症靶、标靶,调态打靶,兼顾整体观念与精准治疗,可提高疗效,延缓其复发时间,从而为临床治疗糖尿病性黄斑水肿提供新思路.
Application of "Combination of State and Target" Strategy in the Treatment of Diabetic Macular Edema
"Differentiation of state and target"is a new clinical differentiation and treatment idea proposed by TONG Xiaolin,academician of Chinese Academy of Sciences,which continues traditional Chinese medicine syndrome differentiation and treatment,and fits modern medical diagnosis and treatment thinking and innovation.It reveals the essence of TCM"state"and the mechanism of modality adjustment,makes the disease perspective more three-dimen-sional,and makes full use of modern pharmacological research results of traditional Chinese medicine to give full play to the advantages of multi-target treatment of traditional Chinese medicine.The use of drugs is more accurate and the treatment is more appropriate.Diabetic macular edema is one of the main causes of decreased central visual acuity in workingage people,and the recurrence rate is high and the control rate is poor due to Western medical treatment in clinical practice.In view of this situation,the academic thought of modality target is applied to identify the state of the disease at different times from a macro perspective,accurately set the target from a micro perspective,adjust the mo-dality and target,and rebuild the disease diagnosis and treatment system to improve clinical efficacy.By learning the connotation of Academician TONG Xiaolin's"combination of state and target"treatment strategy,combined with our team's clinical practice in the treatment of diabetic macular edema,the author distinguished the disease from the"blood stasis"state as the cause,the"loss"state as the result,the pre-cause and good consequences,from the macro state of blood stasis,the micro state of loss,the combination of disease target,disease target,target,modality and target,tak-ing into account the overall concept and accurate treatment.It can improve the curative effect and delay the recurrence time,so as to provide a new idea for the clinical treatment of diabetic macular edema.

Diabetic macular edemaCombination of state and targetState-Target differentiation and treatment

郭琬盈、罗向霞、梁永林、杨芮、吴雨桐、王嘉鹏

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甘肃中医药大学 甘肃兰州 730000

甘肃省中医院 甘肃兰州 730050

糖尿病性黄斑水肿 态靶结合 态靶辨治

国家自然科学基金兰州市人才创新创业项目

819608882019-RC-62

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(1)
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