Application Effect of Traditional Chinese Medicine Combined with Mecobalamine on Peripheral Neurotoxicity Caused by Oxaliplatin Chemotherapy in Malignant Tumors
Objective:To explore the effect of traditional Chinese medicine combined with methylcobalamin on peripheral nerve toxicity caused by oxaliplatin chemotherapy for malignant tumors.Methods:The clinical data of 82 malignant tumor patients with peripheral nerve toxicity caused by oxaliplatin chemotherapy who were treated from Sep-tember 2020 to September 2022 were retrospectively analyzed,and they were divided into group A according to differ-ent treatment methods(41 cases were treated with methylcobalamin tablets)and Group B(41 cases were treated with modified Huangqi Guizhi Wuwu Decoction and methylcobalamin tablets).The patients in both groups were evaluated for efficacy after a one-month treatment.The peripheral nerve toxicity grading,improvement status,TCM syndrome ef-ficacy,Karnovsky score(KPS),numerical pain rating scale(NRS)score,and nerve conduction velocity before and after treatment were compared between the two groups.Results:After treatment,the peripheral neurotoxicity grades of pa-tients in both groups improved,and the improvement effect of group B was better than that of group A;the effective rate of improvement of neurotoxicity of patients in group B was higher than that of group A;the effective rate of improvement of traditional Chinese medicine syndrome of patients in group B was higher than that of group A;after treatment,the NRS scores of patients in both groups were lower than before treatment,and group B was lower than that of group A;af-ter treatment,the conduction velocities of the median nerve and common peroneal nerve of patients in both groups were higher than those before treatment,and group B was lower than that of group A.group,the differences were statisti-cally significant.Conclusion:Modified Huangqi Guizhi Wuwu Decoction combined with methylcobalamin tablets in the treatment of peripheral neurotoxicity caused by oxaliplatin chemotherapy for malignant tumors can reduce the patient's peripheral neurotoxicity grade and pain level,and improve the peripheral neurotoxicity effect and TCM syndrome ef-ficacy and improve nerve conduction velocity.
万方数据
维普
