Observation on the Efficacy of Tongge No.1 Prescription Combined with Chemotherapy in the First-line Treatment of Advanced Esophageal Cancer with Blood Stasis and Diaphragm Obstruction
This study aims to observe the efficacy and safety of Tongge No.1 formula combined with firstline chemo-therapy in the treatment of advanced stage esophageal cancer with blood stasis obstruction.Method:A retrospective analysis was conducted on the clinical data of 80 patients with advanced esophageal cancer who met the criteria of blood stasis obstruction.Divided into an experimental group(n=40)and a control group(n=40).The experimental group received firstline treatment with chemotherapy combined with our hospital's Tongge No.1 formula,while the con-trol group received firstline treatment with simple chemotherapy.Statistical analysis was conducted on the objective response rate(ORR),disease control rate(DCR),pain numerical score(NRS),physical condition score(KPS),tradi-tional Chinese medicine syndrome score,changes in blood levels of squamous cell carcinoma(SCC),carcinoembryonic antigen(CEA),and incidence of chemotherapy related toxic side effects in two groups of patients.Result:The DCR of the experimental group and the control group were 82.5%and 62.5%,respectively,and the experimental group showed a significant improvement compared to the control group(P＜0.05).After treatment,both the experimental group and the control group showed a significant decrease in NRS scores(P＜0.05),and the experimental group showed a more signifi-cant decrease compared to the control group(P＜0.05).After treatment,there was no significant change in the KPS score of the experimental group patients(P＞0.05),while the KPS score of the control group patients decreased significantly(P＜0.05),and the experimental group was significantly higher than the control group(P＜0.05).After treatment,some patients in the experimental group and control group showed a significant decrease in traditional Chinese medicine syndrome scores(P＜0.05),and the degree of reduction in the experimental group was significantly higher than that in the control group(P＜0.05).The incidence of bone marrow suppression,gastrointestinal reactions,and levels of SCC and CEA in the blood of the experimental group were significantly lower than those of the control group at any level after treatment(P＜0.05).Conclusion:The combination of Tongge No.1 formula and firstline chemotherapy may improve the DCR of advanced stage blood stasis obstructed esophageal cancer,alleviate pain related to esophageal cancer,improve some traditional Chinese medicine syndromes,lower the levels of SCC and CEA in the blood,alleviate chemotherapy related toxic side effects,and to some extent improve the quality of life of patients.
万方数据
维普
