首页|力元汤联合质子泵抑制剂口服对慢性胃炎患者中医症状及胃镜检查的影响

力元汤联合质子泵抑制剂口服对慢性胃炎患者中医症状及胃镜检查的影响

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目的:研究力元汤联合质子泵抑制剂口服对慢性胃炎患者中医症状及对胃镜检查疗效的影响.方法:150 例慢性胃炎患者随机分为对照组和研究组,每组 75 例,对照组常规使用质子泵抑制剂(奥美拉唑肠溶片)口服治疗,观察组在口服西药基础上联合使用力元汤进行治疗.对比两组治疗前后中医证候积分、胃镜检查疗效、胃黏膜形态及功能实验室指标及不良反应情况.结果:治疗 2 周后,与对照组相比,研究组中医证候积分(上腹不适、胃脘胀痛、返酸、食欲不振)相对较低、胃镜治疗有效率较高、血清胃蛋白酶原Ⅰ(PGⅠ)和血清胃泌素(GAS)水平较高、血清胃蛋白酶原Ⅱ(PGⅡ)水平较低(P<0.05);两组在药物相关不良反应发生率上无显著差异(P>0.05).结论:慢性胃炎患者选择力元汤联合质子泵抑制剂口服方案治疗,可促进临床症状改善及胃黏膜修复,保证总体治疗效果,且用药方案安全性表现优异,具备临床推广应用价值.
The Effect of Liyuan Tang Combined with Proton Pump InhibitorOral Administration on Traditional Chinese Medicine Symptoms and Gastroscopy Examination in Patients with Chronic Gastritis
Objective:To study the effect of Liyuan Tang combined with proton pump inhibitors on traditional Chinese medicine symptoms and gastroscopy efficacy in patients with chronic gastritis.Method:150 patients with chronic gastritis were randomly divided into a control group and a study group,with 75 cases in each group.The control group received conventional oral treatment with proton pump inhibitors(omeprazole enteric coated tablets),while the observation group received combined treatment with Liyuan Tang on the basis of oral Western medicine.Compare the traditional Chinese medicine syndrome scores,gastroscopy efficacy,gastric mucosal morphology and function laboratory indicators,and ad-verse reactions before and after treatment between two groups.Result:After 2 weeks of treatment,compared with the con-trol group,the study group had relatively lower traditional Chinese medicine syndrome scores(upper abdominal discom-fort,epigastric distension and pain,acid reflux,and loss of appetite),higher effective rates of gastroscopy treatment,higher levels of serum pepsinogen I(PG I)and serum gastrin(GAS),and lower levels of serum pepsinogen II(PG II)(P<0.05);There was no significant difference in the incidence of drug-related adverse reactions between the two groups(P>0.05).Conclusion:The combination of Liyuan Tang and proton pump inhibitor oral regimen can promote clinical symptom improvement and gastric mucosal repair in patients with chronic gastritis,ensuring overall treatment effective-ness.The medication regimen has excellent safety performance and has clinical promotion and application value.

Li Yuan TangProton pump inhibitorsChronic gastritisTraditional Chinese medicine symptomsgastroscope

马春明、张勋中

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河南省项城市中医院 河南周口 466200

力元汤 质子泵抑制剂 慢性胃炎 中医症状 胃镜

全国基层名老中医专家传承工作室项目

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(1)
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