Study on the Mechanism of "Corus officinalis-Cuscuta" in Treating Chronic Glomerulonephritis
Objective: To explore the mechanism of action of Cornus officinale-Cuscutae in the treatment of chronic glomerulonephritis (CGN) based on the network pharmacology platform. Methods: The traditional Chinese medicine systems pharmacology database and analysis platform TCMSP were used to screen out the effective active ingredients and corresponding targets of Cornus officinale and Cuscuta japonica, and the gene targets related to chronic glomeru-lonephritis were obtained through the GeneCards database, and the Venny website was used to obtain information on drugs and diseases. By intersecting the targets, the potential targets of the Cornus officinale-Cuscutae drug pair for the treatment of chronic glomerulonephritis were obtained. Use the STRING database to construct a protein interaction network, then use Cytoscape3.9.1 and the MCODE plug-in to screen out core targets and core drug components, and use the Metascape database to perform GO and KEGG pathway enrichment analysis on the targets. Results: 30 potential active ingredients and 235 potential drug targets of Cornus officinale-Cuscuta drug pair were obtained, of which 9 are core targets for the treatment of CGN. The targets are mainly involved in blood circulation, cell response to organic cy-clic compounds, and phosphorylation. Biological processes such as positive regulation act on CGN, involving 82 KEGG pathways, 24 GO cell components (CC), 38 molecular functions (MF), and 394 biological processes (BP). Conclusion: Cornus officinale-Cuscuta drug pair treats CGN through "multi-targets-multi-pathways-multi-pathways". This study provides a theoretical basis for further elaborating its mechanism of action on glomeruli.
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