Study on the Mechanism of Action of Pseudostellariae Radix Pseudostellariae-Moutan bark Medicine in the Treatment of Diabetic Cardiomyopathy based on Network Pharmacology
Objective: To explore the mechanism of action of Radix Pseudostellariae-Moutan bark medicine in the treatment of diabetic cardiomyopathy. Methods: The network pharmacology method was used to predict active ingredi-ent candidate targets with the help of Traditional Chinese Medicine System Pharmacology Analysis Platform (TCMSP), Pubchem website, and Swiss Target Prediction database. The target genes of diabetic cardiomyopathy were screened out through the Disgenet and GeneCards databases, the intersection targets of traditional Chinese medicine and diseases were obtained using Venny diagram, the protein interaction network diagram was established through the STRING da-tabase, and the network diagram was optimized through Cytoscape 3.9.0 software. Screen out core targets. The Metas-cape database was used to perform GO analysis and KEGG enrichment analysis on the intersection targets. Results: A total of 19 active ingredients and 277 action targets were screened out for traditional Chinese medicine, 2424 disease targets were screened out for diabetic cardiomyopathy, and 109 intersection targets were obtained through the Venn di-agram. Through drug-active ingredient-target network diagram analysis, it can be concluded that kaempferol, querce-tin, robinin, and luteolin may play an important role in the treatment of diseases. From the PPI network diagram, it can be seen that the core targets are TNF, AKT1, SRC, TP53, EGFR, etc. According to KEGG analysis, it is predicted that the drug will exert its therapeutic effect on diabetic cardiomyopathy mainly by intervening in cancer, MAPK, PI3K-Akt and other signaling pathways. Conclusion: Pseudostellariae Radix Pseudostellariae - Moutan peel drug pair can protect diabetic cardiomyopathy through multiple active ingredients, multiple targets, and multiple pathways, providing new ideas for the future prevention and treatment of diabetic cardiomyopathy.
万方数据
维普
